Written By: IJCP Editorial Team

Published On: 12 May, 2023 5:41 PM | Updated On: 19 May, 2024 3:41 PM

A pregnancy with markedly elevated alkaline phosphatase

A report describes a case of a 21-year-old woman who presented at 34 weeks of her first pregnancy for a routine prenatal check-up with unremarkable Past medical history.

Examination revealed slight tenderness on the right upper quadrant. The patient denied any episodes of headaches or visual disturbances. Her vital signs fell within normal ranges, and Serial blood pressure readings were all acceptable. Laboratory examination revealed minimal proteinuria. Workup showed a gross alkaline phosphatase (ALP) elevation at 2800 U/L. However, her previous values of ALP were at most 170 U/L.

 A detailed history revealed no previous bone, renal, or liver disease history. Hepatic, endocrine, and renal functions fell within normal ranges. Abdominal and pelvis ultrasound revealed a vital fetus, with no pathological findings like biliary stones or biliary duct dilatation. 

Serial monitoring for alkaline phosphatase displayed a high peak at 4001 U/L on the delivery day. 

The patient had an uneventful vaginal delivery, and her baby stayed in a good state, with Apgar's score as 7 and 9 in 1 and 5 minutes. The patient received advice to have close contact with her baby. A full workup for the baby showed no critical findings. 

Postpartum monitoring alkaline phosphatase declined to the normal range on week 7 (103 U/L). The pathology of the placenta showed mild chorioamnionitis and no noteworthy infarction.

Alqralleh M, Al-Hajjaj M, Alasfoor S, SalmanA report describes a case of a 21-year-old woman who presented at 34 weeks of her first pregnancy for a routine prenatal check-up with unremarkable Past medical history.

Examination revealed slight tenderness on the right upper quadrant. The patient denied any episodes of headaches or visual disturbances. Her vital signs fell within normal ranges, and Serial blood pressure readings were all acceptable. Laboratory examination revealed minimal proteinuria. Workup showed a gross alkaline phosphatase (ALP) elevation at 2800 U/L. However, her previous values of ALP were at most 170 U/L.

 A detailed history revealed no previous bone, renal, or liver disease history. Hepatic, endocrine, and renal functions fell within normal ranges. Abdominal and pelvis ultrasound revealed a vital fetus, with no pathological findings like biliary stones or biliary duct dilatation. 

Serial monitoring for alkaline phosphatase displayed a high peak at 4001 U/L on the delivery day. 

The patient had an uneventful vaginal delivery, and her baby stayed in a good state, with Apgar's score as 7 and 9 in 1 and 5 minutes. The patient received advice to have close contact with her baby. A full workup for the baby showed no critical findings. 

Postpartum monitoring alkaline phosphatase declined to the normal range on week 7 (103 U/L). The pathology of the placenta showed mild chorioamnionitis and no noteworthy infarction.

Alqralleh M, Al-Hajjaj M, Alasfoor S, Salman Z, Mohammad Salman FB, et al. A pregnant with markedly elevated alkaline phosphatase: a case report. Clin J Obstet Gynecol. 2023; 6: 026-027. DOI: 10.29328/journal.cjog.1001124

Z, Mohammad Salman FB, et al. A pregnant with markedly elevated alkaline phosphatase: a case report. Clin J Obstet Gynecol. 2023; 6: 026-027. DOI: 10.29328/journal.cjog.1001124