A Review of the Health Benefits of Ghee for Bone and Joint Health

Ghee, a traditional clarified butter, has long been valued in Ayurvedic medicine for its health benefits. Recent scientific research is beginning to uncover the molecular mechanisms by which ghee may promote bone and joint health. This review examines the bioactive components of ghee, such as short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs), and fat-soluble vitamins (A, D, E, K2), and their potential therapeutic effects on bone density, joint lubrication, and inflammation.

SCFAs in ghee may enhance joint lubrication and reduce inflammation, while MCFAs and conjugated linoleic acid (CLA) possess anti-inflammatory properties that influence cytokine production and oxidative stress. Vitamins D and K2 are critical for calcium metabolism and bone mineralization, and vitamin A contributes to immune regulation and cartilage health.  This review provides traditional knowledge and modern scientific findings, suggesting that ghee could serve as a complementary therapy for conditions like osteoporosis and arthritis. Below section highlights the valuable effects of ghee on bone density and joint health.

Beneficial effects of Ghee on Bone Density

Ghee is rich in fat-soluble vitamins, particularly Vitamin K2, which strengthens bones by promoting protein carboxylation and inhibiting bone resorption. It works in tandem with Vitamin D to enhance calcium absorption and bone growth.

Additionally, ghee contains beneficial fatty acids like CLA, which support osteoblast differentiation and reduce osteoclast activity. Overall, the combination of these nutrients in ghee significantly promotes bone health.

Beneficial effects of Ghee on Joint Health

Vitamin K2 supports cartilage by promoting matrix protein synthesis. Vitamin D enhances cartilage health through the production of type II collagen and aggrecan, while regulating MMPs to prevent breakdown and protect against osteoarthritis. Vitamin E protects cartilage from oxidative damage and maintains synovial fluid quality. 

Vitamin A supports chondrocyte health, and SCFAs and CLA inhibit MMP activity to preserve cartilage integrity. MUFAs protect cartilage cells, and omega-3 PUFAs stimulate essential cartilage component production, improving flexibility and reducing friction.

Source: Falahatzadeh M, et al. From tradition to science: Possible mechanisms of ghee in supporting bone and joint health, Prostaglandins & Other Lipid Mediators. 2024;75(106902). ISSN 1098-8823. https://doi.org/10.1016/j.prostaglandins.2024.106902.