Written By: IJCP Editorial Team

Published On: 17 Sep, 2022 11:46 AM | Updated On: 14 May, 2024 9:40 PM

Bilateral blurry vision in a 9-year-old boy

A report describes a case of a 9-year-old boy with no significant medical history who complained of painless blurry vision for two days. He also had dizziness and a mild frontal headache and denied any recent trauma or illness. His vision changes started at school and worsened the next day, allowing him to see only the outlines and shapes of objects.

On examination, his vital were within normal limits. Still, he struggled to distinguish shapes or count fingers on visual field testing, thus was consulted with an ophthalmologist, who noted bilateral optic disc swelling on fundoscopy.

Initial work-up showed a mildly elevated erythrocyte sedimentation rate and C-reactive protein, with unremarkable complete blood cell count and basic metabolic results.

Brain MRI showed abnormal thickening and enhancement of the optic nerves with bilateral papilledema. He had normal magnetic resonance venography. Follow-up orbital MRI confirmed bilateral optic neuritis.

MRI spine showed no irregularities.

Lumbar puncture showed regular opening pressure and mild pleocytosis. The remaining cerebrospinal fluid (CSF) studies were unremarkable, including the absence of oligoclonal bands. He was negative for any infectious studies (HIV, syphilis, varicella, interferon γ-release assay, herpes simplex virus 1/2 plasma polymerase chain reaction, Lyme reflex) and rheumatologic studies (antinuclear antibodies, antineutrophil cytoplasmic antibodies).

The patient showed positive serum MOG antibody and negative AQP4, suggesting myelin oligodendrocyte glycoprotein antibody disease (MOG-AD) as the underlying cause of his bilateral optic neuritis.

He was given pulse-dose IV corticosteroids and underwent plasma exchange (PLEX) 5 times over ten days. His Visual acuity advanced from perceiving only hand motions at admission to 20/100 and 20/200 in the right and left eyes, respectively, upon discharge. Fundoscopy showed residual optic disc edema and temporal pallor.

The patient continued taking oral prednisone with a slow taper over several months. His visual acuity gradually improved to 20/40 and 20/30 in the right and left eye, respectively, but initial optic disc swelling led to permanent atrophy and thinning of his optic nerves.

Further, the patient developed multiple Cushingoid features causing a more aggressive prednisone tapering and initiating maintenance immunosuppression with mycophenolate mofetil. Lifelong suppression might not be essential in this case in the absence of future relapses.

Zero O, Lorenz ML. Bilateral blurry vision in a 9-year-old boy. Contemporary pediatrics. July 29, 2022. https://www.contemporarypediatrics.com/view/bilateral-blurry-vision-in-a-9-year-old-boy