Characterizing Sensitive Skin in Pediatric Population

Evidence based observations suggest that pathophysiology of sensitive skin in infants poses significant challenges, primarily due to the reliance on self-reported assessments. This study aimed to identify and characterize sensitive skin in children for the first time using a newly developed parent-reported questionnaire, which was also tested on adults. The study assessed hydration levels, transepidermal water loss (TEWL), and inflammatory markers, including cytokines and polyunsaturated fatty acids (PUFAs).

The study revealed the following findings:

• The study included total of 77 children and 20 adults participated, with 33 children and 10 adults having sensitive skin. 
• Children with sensitive skin exhibited more clinical signs of dryness and lower skin hydration compared to those without sensitive skin. 
• However, TEWL levels were comparable between both groups in infants and adults. 
• Notably, sensitive skin was associated with elevated levels of cytokines and proinflammatory PUFAs, alongside reduced levels of anti-inflammatory PUFAs.

In conclusion, the research indicated that sensitive skin syndrome in infants is characterized by normal skin barrier function but lower hydration levels. The increased presence of proinflammatory markers suggests a link to low-level inflammation. This study is the first to propose that PUFAs may play a role in sensitive skin syndrome in infants, highlighting the need for further investigation into the underlying mechanisms and potential implications for treatment. 

Source: Boyer G, Belilovsky CD, Brédif S, Baudouin C, Misery L, Bellemère G. Clinical and Instrumental Exploration of Sensitive Skin in a Pediatric Population. Cosmetics. 2021; 8(2):43. https://doi.org/10.3390/cosmetics8020043