The current retrospective study aimed to outline the clinical progression and outcomes of 33 patients with Kawasaki disease (KD) who were treated with cyclosporine (CSA) due to coronary artery abnormalities (CAA) or resistance to treatment.The researchers examinedKD patients treated between 2013 and 2023 for CAA or treatment resistance. The analysis included demographics, lab results, medications, adverse events, and echocardiographic findings.
The results revealed:
Thus, the study concluded that CSA is well tolerated in patients with KD experiencing CAA or treatment resistance. This study adds to the limited existing literature on the use of CSA in KD, offering dosing recommendations and emphasizing the need for careful monitoring.
Source: Bellicini I, Bainto E, Shimizu C, Burns JC, Tremoulet AH. Cyclosporine Treatment in Patients with Kawasaki Disease and Coronary Artery Aneurysms or Treatment Resistance. J Pediatr. 2025 Apr;279:114479. doi: 10.1016/j.jpeds.2025.114479. Epub 2025 Jan 24. PMID: 39863079.
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