Continuous Renal Replacement Therapy in Pediatric Patients with Hepatitis A Virus Associated ALF with Advanced Hepatic Encephalopathy – Effect on Survival
Continuous Renal Replacement Therapy in Pediatric Patients with Hepatitis A Virus Associated ALF with Advanced Hepatic Encephalopathy – Effect on Survival
Published On: 05 Aug, 2023 1:05 PM | Updated On: 05 Aug, 2023 3:50 PM
Continuous Renal Replacement Therapy in Pediatric Patients with Hepatitis A Virus Associated ALF with Advanced Hepatic Encephalopathy – Effect on Survival
Continuous renal replacement therapy (CRRT) is increasingly used for nonrenal indications in ICU.
Early use of CRRT in acute liver failure (ALF) for hyperammonemia and HE III/IV is popular.
However, only retrospective studies are available in ALF.
Radionuclide computed tomography (RCT) on CRRT in nonrenal settings (septic shock) has shown no survival benefit.
CRRT does not increase survival in ALF HE III/IV.
CRRT does not affect bilirubin and inotrope requirement; decreases ammonia.
KCH and failure to reduce ammonia are predictors of mortality.
RCT is required to assess the effect of CRRT on survival.
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