Dexpanthenol for Atopic Dermatitis

Atopic dermatitis (AD), an inflammatory skin disease of multiple phenotypes and endotypes, is highly prevalent in children. people of all ages, including active adolescents, pregnant women, and the elderly, suffer from AD, encountering chronicity, flares, and unexpected relapse. 

Dexpanthenol possesses multiple pharmacological effects and is used to treat various skin disorders, like AD. The present study summarized the up-to-date evidence relating to dexpanthenol and provided a consensus on how to use dexpanthenol effectively to treat AD. 

The study reviewed all the evidence on the application and efficacy of dexpanthenol in AD. The literature search focused on dexpanthenol use and improving skin barrier function, preventing acute flares, and its topical corticosteroid (TCS) sparing effects. It also summarized evidence and recommendations for special groups such as pregnant women and the impact of dexpanthenol and emollient plus in maintenance therapy. 

The study found Dexpanthenol to be effective and well-tolerated for the treatment of AD. It improves skin barrier function, reduces acute and frequent flares, has a significant TCS-sparing effect, and enhances wound healing for skin lesions. 

This study advises clinicians and patients on the proper maintenance treatment of AD. Dexpanthenol, an active ingredient in ointments or emollients, is suitable for treating and maintaining AD. Hence, dermatologists and clinicians should consider dexpanthenol as a treatment option for mild to moderate AD.

Cho YS, Kim HO, Woo SM, Lee DH. Use of Dexpanthenol for Atopic Dermatitis—Benefits and Recommendations Based on Current Evidence. Journal of Clinical Medicine. 2022; 11(14):3943. https://doi.org/10.3390/jcm11143943