Fertility-Preserving Surgery for Granulosa Cell Tumor with a Teratoma

A report describes a case of a 24-year-old nulligravid woman who presented with a three-month history of persistent lower abdominal pain. Clinical examination showed two palpable and firm masses (measuring about 6-8 cm) on both adnexa. A CT scan revealed two cystic, fatty, and non-enhancing lesions in the right and left ovary with no abdominal fluid. She was advised ovarian cystectomy due to bilateral cystic teratomas. The surgical procedure revealed 20 milliliters of abdominal fluid, with no suspected metastasis in the peritoneal cavity. Masses on the right and the left ovary comprised cysts of hair, tufts, and sebaceous materials, accompanied by solid tissue that colonized most of the remaining ovarian parenchyma. A bilateral oophorectomy was performed to preserve the patient's fertility. She received a histopathological diagnosis of mature cystic teratomas coexisting with granulosa cell tumors on both ovaries. 

Six months after the operation, the patient has no sign of recurrence. She received combined oral contraceptive pills (0.03 mg ethinylestradiol and 0.15 mg desogestrel) as hormone replacement therapy.

Nha PB, Tuyen PV, Ha NV, et al. Fertility-Preserving Surgery in a Young Nulligravid Woman with Bilateral Coexistence of a Granulosa Cell Tumor with a Teratoma. Case Reports in Obstetrics and Gynecology. 2023; 2023. https://doi.org/10.1155/2023/9438575