Levels of Renin and D-dimer in women with polycystic ovary disease

Polycystic ovarian syndrome (PCOS), an endocrinological disorder, is common among women of childbearing age. Coronavirus disease 2019 (COVID-19), an acute respiratory disease, is due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infestation. The association between PCOS and COVID has yet to be made clear. The present study determined the levels of renin, D-dimer, and some relevant biomarkers in patients with PCOS (with and without COVID-19). It included 120 women [80 PCOS women (40 with COVID-19 and 40 without COVID-19) and 40 non-PCOS women (20 with COVID-19 and 20 without)] within the age range of 15–40 years. 

The study collected the blood samples from participants and evaluated biochemical parameters by ELISA (renin and D-dimer), VIDAS (sex hormones: LH, FSH, and testosterone), and colorimetric methods (serum lipids and glucose concentrations). It observed-

• Significantly higher Renin and D-dimer levels in PCOS groups compared to non-PCOS groups. 
• Significant elevation in luteinizing hormone, fasting blood glucose, and serum lipid tests (total cholesterol, triglycerides, and low-density lipoprotein) in PCOS patients compared to non-PCOS women. 
• Lower levels of high-density lipoprotein and follicle-stimulating hormone levels in PCOS patients. 
• A highly significant increase in renin and D-dimer levels in PCOS patients with COVID-19. 

This study shows that higher levels of renin and D-dimer are found in PCOS patients' groups and non-PCOS participants with COVID-19. Therefore, assessing renin and D-dimer may provide helpful information to the physician in PCOS and attract attention to a higher possibility of forming clots in the patient's blood, especially after infection with coronavirus (SARS-CoV-2).

Ali SE, Khaleel FM, Ali FE. Estimation of renin and D-dimer levels in women with polycystic ovary disease with or without coronavirus infection. Baghdad Journal of Biochemistry and Applied Biological Sciences. 2022;3(04):286- 298. doi: bjbabs.v3i04.151