Non-traditional Risk Factors for ASCVD

• Most MIs occurs in young patients without risk factors; 1.1 million patients <55 years with MI.

• Multiple non-traditional risk factors for ASCVD

• Frailty, ADL, glaucoma, arthritis, sinusitis, incontinence, social dependence for personal care.

• Risk enhancing factors for clinician-patient risk discussion

• Family history of premature ASCVD

• Primary hypercholesterolemia

• Metabolic syndrome

• Chronic kidney disease (CKD)

• Chronic inflammatory conditions

• History of premature menopause and history of a pregnancy-associated condition that increases later ASCVD risk

• Lipid biomarkers associated with increased ASCVD risk.