Written By: IJCP Editorial Team

Published On: 11 Apr, 2024 1:56 PM | Updated On: 11 Apr, 2024 2:19 PM

Primary Immunodeficiency Disorders in Hospitalized Children

A recent study evaluated the incidence and kinds of primary immunodeficiency diseases (PIDs) in hospitalized children (upto 12years). It screened the children for suspected IPD using Jeffrey Modell Foundation (JMF) Criteria; and further evaluated them if they satisfied at least 2 out of 10 warning signs.

The study found that-

• Of the 33,204 hospital admissions, 50 children satisfied the JMF criteria. 

• Of these 50 children, 27 were finally diagnosed with an underlying PID.

• The prevalence was calculated as 1 in 1000 hospitalized children. 

• 37.03% of them had antibody deficiency, and 33.3% had a phagocytic defect. 

• The commonest PID was Chronic granulomatous disease, followed by common variable immunodeficiency. 

• 62.97% of children had respiratory infections, and Acinetobacterbaumannii was the commonest isolated organism. 

This study presents the prevalence of PIDs in eastern India. Implementing a systematic, step-by-step clinical and diagnostic approach can help early identification and prompt therapeutic interventions. Such approaches are crucial in improving patient outcomes and enhancing overall management strategies for primary immunodeficiency diseases.

 Sabui TK, Manna MK, Chatterjee M, et al. Spectrum of Primary Immunodeficiency Disorders in Hospitalized Children: Multicentric Data From Kolkata. Indian Pediatrics. 2024;61