Role of Modified ISTH DIC Score in Cases of Abruptio Placentae

Disseminated intravascular coagulation (DIC), a potentially fatal condition, occurs secondary to an underlying disorder, with abruption being the most common cause in obstetrics.

The present study analyzed the modified International Society of Thrombosis and Haemostasis DIC score for predicting DIC in abruptio placentae cases. It also correlated the score with the severity of the abruption to optimize its use in limited resource settings.

The study included individuals diagnosed with Abruptio Placentae and a more than 28 weeks gestation period. A modified ISTH DIC score with a value > 26 suggested a high probability of DIC. 

The results indicated that 37.3% of patients with abruptio placentae had a high probability of DIC and all needed blood/blood product transfusion. Among these, 80.85% had Grade 3 abruption, while 19.15% had Grade 2 abruption. Furthermore, there was a significant association between the grade of abruption and the modified ISTH DIC score.

Anticipating and early predicting disseminated intravascular coagulation can aid in the timely management of participants at risk. Hence, the Modified ISTH DIC Score should be used for early prediction of DIC in cases of abruptio placentae, particularly in Grade 2 and Grade 3 abruption, to lower overall maternal morbidity and mortality.

Chou T, Thakur A, Singh KN. Analysis of Modified ISTH DIC Score in Cases of Abruptio Placentae and Its Correlation with Severity of Abruptio Placentae. J ObstetGynecol India. 2024. https://doi.org/10.1007/s13224-023-01928-8