Should We Assess CRP/Albumin Ratio in Polycystic Ovarian Syndrome?

Polycystic ovarian syndrome is often reported among women of reproductive age. It features menstrual abnormalities, hyperandrogenism, and polycystic ovaries, which may, in turn, cause vivid complications. Studies have proposed the role of inflammation in the pathophysiology of PCOS.

Upadhyay N et al., in their study, found the CRP/albumin ratio to be significantly higher in women with PCOS than in healthy controls, along with serum total testosterone and HOMA-IR. 

The available evidence supports the hypothesis that inflammation plays a key role in the pathophysiology of PCOS. Clinicians can, hence, use the CRP/albumin ratio as a cheaper biochemical marker of the disease. However, more studies should validate this marker to establish its use in the Indian population.

Upadhyay N, Almeida EA, Singh A., et al. Evaluation of CRP/Albumin Ratio in Polycystic Ovarian Syndrome. J ObstetGynecol India. 2023. https://doi.org/10.1007/s13224-023-01897-y