The Impact of Applying Autologous PRP within the Uterus on EMT and Pregnancy Outcomes

Infertility is a pervasive issue affecting women worldwide, leading to countless cases of reproductive challenges every year. This study sought to assess the efficacy of employing intrauterine infusion of autologous platelet-rich plasma (PRP) in women experiencing suboptimal endometrial conditions during frozen embryo transfer cycles.

It enrolled 61 women between 22 and 40 years of age and, based on hysteroscopy findings, divided them into group A (Normal hysteroscopy findings) and group B (Abnormal hysteroscopy findings). It performed Intrauterine instillation of autologous PRP in women with an endometrial thickness(EMT) of <7 even after giving Estradiolvalerate therapy. The study evaluated an increase in EMT after 48 and 72 hours of PRP infusion and performed Embryo transfer when the endometrium reached an optimal pattern in terms of thickness, appearance, and vascularity.

The study found-

• A significant increase in EMT in Group B compared to Group A.

• No apparent changes in clinical pregnancy rate (CPR), implantation rate (IR), or live birth rate (LBR) between both group. 

• Increase in overall clinical pregnancy and LBR.

This study shows that Autologous platelet-rich plasma increases endometrial thickness and success rate in pregnancy after PRP administration in patients with low EMT undergoing IVF treatment and patients having two or more previous IVF failures.

 Desai K, Desai F, Sharma H, Bambhaniya H, Sharma S, Effect of intrauterine instillation of autologous platelet-rich plasma on endometrial thickness and pregnancy outcome. Indian J ObstetGynecol Res 2023;10(1):36-41