Thiamine Treatment can Reduce Mortality Risk in Acute Non-Infectious Infantile Encephalopathy

Written By: user

IJCP Editorial Team

Published On: 15 Dec, 2023 12:18 PM | Updated On: 15 Dec, 2023 12:18 PM

Thiamine Treatment can Reduce Mortality Risk in Acute Non-Infectious Infantile Encephalopathy

A new study aimed to characterize clinical and investigational findings and assess the impact of thiamine treatment on mortality in patients with acute non-infectious encephalopathy admitted to a Sikkim hospital from 2019-2021.

This was a retrospective study that included 37 patients (median age 4 months) – 62.2% were males, and 75% were exclusively breastfed infants. Ophthalmologic and respiratory abnormalities were observed in 67.6% and 89.2% of patients, respectively, with common multisystem involvement.

Neuroimaging depicted bilateral basal ganglia involvement in 75% of the cases, and one infant had confirmed biochemical thiamine deficiency. It was noted that thiamine treatment was associated with significantly lower mortality, with none of the 11 treated patients succumbing, compared to a 76.9% case fatality rate in the untreated group.

Thus, it was inferred that thiamine use was linked to decreased mortality among patients with acute non-infectious encephalopathy and bilateral basal ganglia involvement.

Source: Gurung B, Bhutia TD, Chettri S, Mummadi MK, Bondre VP. Indian Journal of Pediatrics. 2023 Oct 26:1-3.

IJCP Editorial Team

Comprising seasoned professionals and experts from the medical field, the IJCP editorial team is dedicated to delivering timely and accurate content and thriving to provide attention-grabbing information for the readers. What sets them apart are their diverse expertise, spanning academia, research, and clinical practice, and their dedication to upholding the highest standards of quality and integrity. With a wealth of experience and a commitment to excellence, the IJCP editorial team strives to provide valuable perspectives, the latest trends, and in-depth analyses across various medical domains, all in a way that keeps you interested and engaged.