Use of Triglyceride and glucose index in women with polycystic ovary syndrome

The present study evaluated whether triglyceride and glucose (TyG) indices are useful in identifying insulin sensitivity/resistance in women with polycystic ovary syndrome (PCOS).

It included 172 Korean women aged 18-35 years who were diagnosed with PCOS and calculated Fasting-state insulin sensitivity assessment indices (ISAIs) and abnormal insulin sensitivity. 

The study observed-

• All clinical parameters, except age and other insulin resistance-related biochemical parameters, significantly related to the TyG index. 

• An optimal TyGcutoff value is 8.126 (sensitivity, 0.807; specificity, 0.683) for identifying abnormal insulin sensitivity. 

• All ISAIs and lipid profile parameters differed significantly between TyG groups.

This study proves the TyG index to be a feasible surrogate marker for predicting insulin sensitivity/resistance in women with PCOS.

Kwon S, Heo A, Chun S. Triglyceride and glucose index for identifying abnormal insulin sensitivity in women with polycystic ovary syndrome. ObstetGynecol Sci. 2023 Jul;66(4):307-315. doi: 10.5468/ogs.23103. Epub 2023 Jun 28. PMID: 37376795; PMCID: PMC10375216.