Vitamin D Deficiency and Metabolic Syndrome In patients with Polycystic Ovarian Disorder (PCOD) Along With Anti-Mullerian Hormone Levels

Vitamin D supplementation is widely prescribed for many lifestyles related and metabolic disorders. The present study assessed the status of Vitamin D concerning metabolic syndrome and Anti-Mullerian Hormone (AMH, marker of disease severity) levels in PCOD patients in a rural area of Haryana to assess the potential for possible Vitamin D supplementation.

The study enrolled 50 PCOD patients and 50 age-matched healthy controls. It subjected all the participants to clinical examination, anthropometry, lipid profile, fasting glucose, HbA1c, vitamin D and AMH levels.

The study found-

• Significantly higher BMI, waist circumference, fasting glucose, HbA1c, triglycerides, total cholesterol, LDL-cholesterol, and prevalence of dyslipidemia in the study than in control group subjects.
• 34% of patients with PCOD had Metabolic syndrome. 
• Significantly lower Vitamin D levels in PCOD patients. 
• 72% of PCOD patients and 36% of healthy controls suffered Vitamin D deficiency (< 20 ng/mL). 
• Significantly lower Vitamin D levels in PCOD patients with metabolic syndrome than those without metabolic syndrome (12.6±4.71 vs. 20.9±15.32 ng/mL). 
• Inverse correlation between Vitamin D levels and AMH levels in PCOD.

This study shows that Vitamin D deficiency correlates with the severity of PCOD and is most severe in patients with PCOD and metabolic syndrome. Thus, assessing vitamin D levels may be helpful, especially in PCOD patients with metabolic syndrome suggesting the possible benefit of vitamin D supplementation.

Bansal P, Yadav K, Kansal R. Vitamin D Deficiency And Metabolic Syndrome In Polycystic Ovarian Disorder (Pcod) Patients Along With Anti-Mullerian Hormone Levels. Journal of Pharmaceutical Negative Results 2022:6163–6172. https://doi.org/10.47750/pnr.2022.13.S07.749